Disintegrin - Like Metalloproteinase ADAM 10 and Shed by the Activity of the α and TNF - γ Ligand 16 Is Induced by IFN - The Transmembrane CXC - Chemokine

The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN- and TNF- and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.

The novel CXC-chemokine ligand 16 (CXCL16) functions as transmembrane adhesion molecule on the surface of APCs and as a soluble chemoattractant for activated T cells. In this study, we elucidate the mechanism responsible for the conversion of the transmembrane molecule into a soluble chemokine and provide evidence for the expression and shedding of CXCL16 by fibroblasts and vascular cells. By t...

Alterations in Gene Expression of Interferon and Tumor Necrosis Factor‐α in Human Blood Macrophage-Like Monocytes Induced by Clinical and Standard Salmonella typhi Strains in vitro

Background and Objective: Salmonella typhi as a human pathogen stimulates the human immune system and triggers gene expression changing its pathogenesis. Therefore, we aimed to investigate the expression levels of ifn-γ and tnf-α cytokines in human blood macrophage-like monocytes in dealing with clinical and standard samples of Salmonella typhi in vivo. Materials and Methods: In this cross-sec...

The Effect of Moderate and High Intensity Endurance Trainings with Genistein on TNF- α and IFN- γ in Streptozotocin Induced Diabetic Rats

Objective: The purpose of this study was to investigate the effect of moderate and high intensity endurance trainings with genistein consumption on tumor necrosis factor alpha (TNF- α) and interferon gamma (INF- γ) in streptozotocin induced diabetic rats. Materials and Methods: In this experimental study, 64 male diabetic rats were randomly assigned into 8 groups of 8 (1) first week control (2...

Efficacy of Spirulina platensis on immune functions in cancer mice with systemic candidiasis

The aim of this study was to investigate the immunomodulatory effects of Spirulina platensis (S.platensis) by measuring the levels of serum interleukin (IL)-4, IL-10, IL-17, tumor necrosis factor(TNF)-α and interferon (IFN)-|γ| in mice suffered from systemic candidiasis and breast cancer. Theaqueous extract of S. platensis was selected for this study. Balb/C female mice were inoculated withCand...